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The Gut Microbiome’s Role in Gout: A New Frontier for Uric Acid Control

Gout, a metabolic disorder characterized by hyperuricemia and urate crystal deposition, has traditionally been managed through pharmacological interventions targeting uric acid production or excretion.

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Dietary Strategies and Natural Supplements: Bridging Tradition and Science

The 2019 Chinese Society of Endocrinology guidelines advocate for a purine-restricted diet (<200 mg/day) to mitigate gout risk.

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Diuretics and Beyond: Enhancing Renal Uric Acid Excretion
The Diuretic Dilemma

Loop diuretics like furosemide, widely used for hypertension, paradoxically exacerbate hyperuricemia by reducing renal urate excretion.

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Nighttime Gout Attacks: Mechanisms and Non-Pharmacological Interventions

Nighttime gout flares result from decreased body temperature (reducing urate solubility) and circadian dips in cortisol (exacerbating inflammation).

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Innovations in Crystal Dissolution: From Surgery to Oral Therapeutics

Surgical tophi excision, while effective, carries risks of infection and recurrence. Pharmacological options like pegloticase (a PEGylated uricase) are costly and require biweekly infusions, limiting accessibility.

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Holistic Management: Integrating Lifestyle, Supplements, and Monitoring

Gout rarely exists in isolation; 65% of patients have hypertension, 40% diabetes, and 30% CKD.

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