Can high uric acid (hyperuricemia) be fully cured? The answer is nuanced: hyperuricemia can achieve clinical remission—meaning uric acid levels return to a healthy range, excess urate crystals stop forming, gout attacks cease, and existing tophi (gouty deposits) gradually dissolve. This goal is absolutely achievable with proper management. However, a permanent “cure” that allows unrestricted diet and lifestyle without ever raising uric acid again is currently not possible.
Hyperuricemia is fundamentally a chronic metabolic disorder closely tied to genetic factors and long-term lifestyle habits. It requires ongoing, consistent control to coexist peacefully with good health.
Why Hyperuricemia Is Difficult to “Cure”: The Root Causes
Uric acid in the body comes from two main sources: about 20% from purine-rich foods in the diet, and 80% produced internally through normal cell metabolism. Most uric acid is excreted by the kidneys in urine. Hyperuricemia develops when uric acid production is excessive or kidney excretion is insufficient, causing blood levels to rise above normal.
The “non-curable” nature of hyperuricemia stems from the combined effects of genetics, metabolic syndrome, and lifestyle factors.
Genetic Factors
During human evolution, we lost the enzyme uricase that breaks down uric acid (unlike most mammals, which convert it to the more soluble allantoin). This makes uric acid the end product of purine metabolism in humans, resulting in naturally higher blood levels compared to other mammals.
Additionally, the kidneys reabsorb uric acid more strongly to help maintain blood pressure in low-sodium environments—an evolutionary adaptation that predisposes humans to higher uric acid. Genetic variations in uric acid production and excretion genes further contribute. Studies show hyperuricemia has a heritability of 45–73%, meaning individual differences in uric acid metabolism are largely inherited.
Metabolic Syndrome
Hyperuricemia often coexists with obesity, insulin resistance, hypertension, dyslipidemia, and impaired glucose metabolism. For example, insulin resistance directly reduces kidney uric acid excretion, creating a vicious cycle. Treating only one condition in isolation rarely improves overall metabolic health.
Lifestyle Factors
Genetic susceptibility is amplified by habits such as frequent consumption of seafood, red meat, rich broths, alcohol (especially beer), and sugary drinks, combined with obesity. These accelerate the development and progression of hyperuricemia.
These factors cause persistent, systemic metabolic disruption. While lifestyle and environmental changes can control the condition, they cannot alter the underlying genetic predisposition. Long-term, consistent management is therefore essential to maintain stable, healthy uric acid levels.
What Uric Acid Level Counts as “Controlled”?
- For patients without tophi: Keeping serum uric acid below 6.0 mg/dL (≈360 µmol/L) long-term halts crystal growth and allows existing deposits to slowly dissolve. This is the minimum target for most gout patients.
- For patients with tophi: Levels should be lowered to below 5.0 mg/dL (≈300 µmol/L) to accelerate tophi dissolution.
Effective Support for Lowering and Stabilizing Uric Acid: BISPIT Goose Muscle Peptide & Acid-Clearing Peptide
In addition to avoiding high-purine foods, staying active, and maintaining a healthy weight, dietary supplements can make uric acid management easier and more effective.
BISPIT Goose Muscle Peptide is a natural dipeptide found in deep-sea fish like tuna. Research shows it reduces uric acid production by inhibiting xanthine oxidase activity while promoting kidney excretion. Its natural antioxidant properties make it a gentle, well-tolerated option. Consistent use has been shown to significantly lower serum uric acid in people with hyperuricemia.
BISPIT Acid-Clearing Peptide uses a refined natural plant-based formula combining celery seed, cassia seed, chicory, poria, and other herbal extracts. These ingredients work synergistically to support metabolism, clear heat, promote diuresis, and gently regulate the internal environment—addressing multiple pathways in uric acid production and excretion.
The Bottom Line: Long-Term Control for a High-Quality Life
Managing hyperuricemia successfully requires steady, long-term commitment rather than expecting a one-time fix. With consistent lifestyle adjustments and appropriate support (including supplements like BISPIT Goose Muscle Peptide and Acid-Clearing Peptide), you can prevent gout flares, protect joint health, restore metabolic balance, and enjoy a healthier, more comfortable life.