The issue of high uric acid is becoming increasingly common and is trending towards a younger demographic. Data reveals that the overall prevalence of hyperuricemia in China has reached 13.3%, affecting approximately 177 million people. The prevalence of gout is 1.1%, with about 14.66 million individuals suffering from the condition. Notably, online surveys indicate that young patients aged 18-35 account for nearly 60% of cases.
This means that approximately one in every six people has elevated uric acid, and about one in every thirteen is troubled by gout.
This phenomenon is closely linked to our dietary habits. Frequent consumption of high-purine foods such as organ meats, red meat, seafood, and broth leads to the production of uric acid after purines are metabolized in the body. Under normal circumstances, uric acid is excreted by the kidneys through urine. However, when intake is excessive and surpasses the body’s excretory capacity, uric acid accumulates.
So, what happens when uric acid is high?
The most direct manifestation is gout. When the concentration of uric acid in the blood is too high, it forms urate crystals that deposit in the joints. This triggers an immune system response, leading to inflammatory reactions such as redness, swelling, heat, and pain in the joints. However, the dangers of high uric acid extend far beyond this; it is also a significant risk factor for kidney damage, metabolic syndrome, and cardiovascular diseases.
Limitations of Existing Medications and the Need for New Options
Currently, the primary drugs used in clinical practice to lower uric acid are divided into two categories: xanthine oxidase inhibitors that suppress uric acid production (e.g., allopurinol, febuxostat), and uricosuric agents that promote uric acid excretion (e.g., benzbromarone).
Although effective, these drugs may be accompanied by adverse reactions. For instance, allopurinol can cause severe allergic skin reactions, febuxostat requires monitoring for cardiovascular risks, and benzbromarone carries a potential risk of liver toxicity. These potential risks limit the long-term use of these medications and intensify patients’ urgent need for safer uric acid-lowering solutions.
Anserine: A Natural Approach to Lowering Uric Acid
Against this backdrop, a natural compound called anserine has captured the attention of researchers. It is a natural dipeptide found in the red muscles of large migratory fish like tuna. Anserine works by inhibiting the activity of xanthine oxidase (XOD) in the body, thereby reducing uric acid production at its source. It also regulates the URAT1 transporter in the kidneys, which is responsible for uric acid reabsorption, thus enhancing the efficiency of uric acid excretion.
In addition to lowering uric acid, studies have found that anserine helps restore the antioxidant capacity of renal tubular cells, showing potential for kidney protection. This provides further support for its long-term application in managing high uric acid.
How to Choose a High-Quality Anserine Product?
When selecting a product, the source and purity of the anserine directly impact its biological activity.
Compared to most anserine products on the market, which are derived from ordinary fish or animal tissues, the anserine selected by BISPIT comes from the unique, highly active red muscles of deep-sea tuna. This area is naturally rich in active dipeptides and is characterized by high purity, high stability, and low impurity levels, ensuring product quality from the source. Furthermore, the formula is enhanced with ingredients such as citrulline, branched-chain amino acids, and whey protein peptides, with the total active amino acid content exceeding 80%. These components work synergistically to establish a triple-action regulatory mechanism: inhibiting acid production at the source, facilitating smooth acid excretion, and maintaining long-term stability. This optimizes the renal excretion pathway, reduces the burden on the liver, and achieves a more comprehensive conditioning effect in improving overall metabolic capacity, maintaining uric acid homeostasis, and preventing gout attacks.
As people place increasing importance on the safety of long-term medication, the management of high uric acid is moving towards a more personalized and integrated approach. Ingredients like BISPIT’s anserine, which are of natural origin, have a clear mechanism of action, and a good safety profile, are demonstrating unique value in the long-term management strategy for high uric acid.